By David Limbaugh
San Francisco 49ers vs Arizona Cardinals NFL Odds & Prop Bets

The rematch of a 24-20 Arizona win in Week 1 has far more significance for the Cardinals (8-6), who remain in the running for an NFC playoff spot, than the 49ers (5-9), whose bid to repeat as conference champs officially ended with last week's loss a
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Game Lines
Game
Spread | Moneyline | Total | |
San Francisco 49ers | +5.0 (-105) | +205 | O 48.5 (-110) |
Arizona Cardinals | -5.0 (-115) | -245 | U 48.5 (-110) |
DRAW | - | - | - |
First Half
Spread | Moneyline | Total | |
San Francisco 49ers | +3.0 (-110) | +145 | O 24.0 (-120) |
Arizona Cardinals | -3.0 (-110) | -190 | U 24.0 (EVEN) |
DRAW | - | - | - |
Second Half
Spread | Moneyline | Total | |
San Francisco 49ers | |||
Arizona Cardinals |
1st Quarter
Spread | Moneyline | Total | |
San Francisco 49ers | +0.5 (-120) | +140 | O 9.5 (-120) |
Arizona Cardinals | -0.5 (-110) | -185 | U 9.5 (-110) |
DRAW | - | - | - |
2nd Quarter
Spread | Moneyline | Total | |
San Francisco 49ers | +0.5 (-110) | +140 | O 14.0 (-105) |
Arizona Cardinals | -0.5 (-120) | -185 | U 14.0 (-125) |
DRAW | - | - | - |
3rd Quarter
Spread | Moneyline | Total | |
San Francisco 49ers | +0.5 (-145) | +135 | O 9.5 (-120) |
Arizona Cardinals | -0.5 (+110) | -180 | U 9.5 (-110) |
DRAW | - | - | - |
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Alternate Lines Score Props Touchdown Props Game Props Punt Props Alternate Lines
Back to Game LinesSan Francisco 49ers @ Arizona Cardinals | Spread
- San Francisco 49ers-1.0 (+190)
- Arizona Cardinals+1.0 (-260)
- San Francisco 49ers+1.0 (+155)
- Arizona Cardinals-1.0 (-210)
- San Francisco 49ers+1.5 (+150)
- San Francisco 49ers-1.5 (+200)
- Arizona Cardinals+1.5 (-275)
- San Francisco 49ers-2.0 (+205)
- Arizona Cardinals+2.0 (-280)
- San Francisco 49ers-2.5 (+205)
- Arizona Cardinals+2.5 (-280)
- San Francisco 49ers+3.0 (+120)
- Arizona Cardinals-3.0 (-160)
- San Francisco 49ers-3.0 (+230)
- Arizona Cardinals+3.0 (-320)
- San Francisco 49ers+3.5 (+110)
- Arizona Cardinals-3.5 (-145)
- San Francisco 49ers-3.5 (+250)
- Arizona Cardinals+3.5 (-360)
- San Francisco 49ers+4.0 (+105)
- Arizona Cardinals-4.0 (-140)
- San Francisco 49ers-4.0 (+275)
- Arizona Cardinals+4.0 (-400)
- San Francisco 49ers+4.5 (-105)
- Arizona Cardinals-4.5 (-130)
- San Francisco 49ers-4.5 (+280)
- Arizona Cardinals+4.5 (-425)
- San Francisco 49ers+5.0 (-125)
- Arizona Cardinals-5.0 (-105)
- San Francisco 49ers-5.0 (+285)
- Arizona Cardinals+5.0 (-425)
- San Francisco 49ers+5.5 (-125)
- Arizona Cardinals-5.5 (-105)
- San Francisco 49ers-5.5 (+300)
- Arizona Cardinals+5.5 (-475)
- San Francisco 49ers+6.0 (-140)
- Arizona Cardinals-6.0 (+105)
- San Francisco 49ers+6.5 (-145)
- Arizona Cardinals-6.5 (+110)
- San Francisco 49ers+7.0 (-160)
- Arizona Cardinals-7.0 (+120)
- San Francisco 49ers+7.5 (-170)
- Arizona Cardinals-7.5 (+125)
- San Francisco 49ers+8.0 (-185)
- Arizona Cardinals-8.0 (+135)
- San Francisco 49ers+8.5 (-200)
- Arizona Cardinals-8.5 (+140)
- San Francisco 49ers+9.0 (-210)
- Arizona Cardinals-9.0 (+145)
- San Francisco 49ers+9.5 (-200)
- Arizona Cardinals-9.5 (+150)
- San Francisco 49ers+10.0 (-220)
- Arizona Cardinals-10.0 (+165)
- San Francisco 49ers+10.5 (-245)
- Arizona Cardinals-10.5 (+170)
- San Francisco 49ers+11.0 (-260)
- Arizona Cardinals-11.0 (+185)
- San Francisco 49ers+11.5 (-275)
- Arizona Cardinals-11.5 (+190)
- San Francisco 49ers+12.0 (-275)
- Arizona Cardinals-12.0 (+200)
- San Francisco 49ers+12.5 (-290)
- Arizona Cardinals-12.5 (+210)
- San Francisco 49ers+13.0 (-320)
- Arizona Cardinals-13.0 (+220)
- San Francisco 49ers+13.5 (-340)
- Arizona Cardinals-13.5 (+230)
- San Francisco 49ers+14.0 (-360)
- Arizona Cardinals-14.0 (+250)
- San Francisco 49ers+14.5 (-370)
- Arizona Cardinals-14.5 (+260)
- San Francisco 49ers+15.0 (-390)
- Arizona Cardinals-15.0 (+270)
- San Francisco 49ers+15.5 (-400)
- Arizona Cardinals-15.5 (+275)
San Francisco 49ers @ Arizona Cardinals | Spread
- San Francisco 49ers - 1H+0.5 (+125)
- Arizona Cardinals - 1H-0.5 (-165)
- San Francisco 49ers - 1H-0.5 (+180)
- Arizona Cardinals - 1H+0.5 (-245)
- San Francisco 49ers - 1H+1.5 (+115)
- Arizona Cardinals - 1H-1.5 (-155)
- San Francisco 49ers - 1H+2.5 (+110)
- Arizona Cardinals - 1H-2.5 (-145)
- San Francisco 49ers - 1H+3.0 (-105)
- Arizona Cardinals - 1H-3.0 (-130)
- San Francisco 49ers - 1H+4.0 (-140)
- Arizona Cardinals - 1H-4.0 (+105)
- San Francisco 49ers - 1H+4.5 (-160)
- Arizona Cardinals - 1H-4.5 (+120)
- San Francisco 49ers - 1H+6.0 (-180)
- Arizona Cardinals - 1H-6.0 (+135)
San Francisco 49ers @ Arizona Cardinals | Total Points O/U
- Over38.0 (-475)
- Under38.0 (+320)
- Over38.5 (-425)
- Under38.5 (+285)
- Over39.0 (-400)
- Under39.0 (+275)
- Over39.5 (-425)
- Under39.5 (+265)
- Over40.0 (-360)
- Under40.0 (+250)
- Over40.5 (-320)
- Under40.5 (+230)
- Over41.0 (-305)
- Under41.0 (+220)
- Over41.5 (-275)
- Under41.5 (+200)
- Over42.0 (-265)
- Under42.0 (+195)
- Over42.5 (-250)
- Under42.5 (+185)
- Over43.0 (-245)
- Under43.0 (+180)
- Over43.5 (-220)
- Under43.5 (+165)
- Over44.0 (-215)
- Under44.0 (+160)
- Over44.5 (-190)
- Under44.5 (+140)
- Over45.0 (-180)
- Under45.0 (+135)
- Over45.5 (-170)
- Under45.5 (+125)
- Over46.0 (-160)
- Under46.0 (+120)
- Over46.5 (-145)
- Under46.5 (+110)
- Over47.0 (-140)
- Under47.0 (+105)
- Over47.5 (-135)
- Under47.5 (EVEN)
- Over48.0 (-125)
- Under48.0 (-105)
- Over48.5 (-115)
- Under48.5 (-115)
- Over49.0 (-105)
- Under49.0 (-125)
- Over49.5 (EVEN)
- Under49.5 (-130)
- Over50.0 (+105)
- Under50.0 (-140)
- Over50.5 (+110)
- Under50.5 (-145)
- Over51.0 (+115)
- Under51.0 (-150)
- Over51.5 (+120)
- Under51.5 (-160)
- Over52.0 (+130)
- Under52.0 (-170)
- Over52.5 (+130)
- Under52.5 (-175)
- Over53.0 (+140)
- Under53.0 (-190)
- Over53.5 (+150)
- Under53.5 (-200)
- Over54.0 (+160)
- Under54.0 (-215)
- Over54.5 (+165)
- Under54.5 (-220)
- Over55.0 (+170)
- Under55.0 (-230)
- Over55.5 (+185)
- Under55.5 (-250)
- Over56.0 (+190)
- Under56.0 (-260)
- Over56.5 (+195)
- Under56.5 (-265)
- Over57.0 (+220)
- Under57.0 (-305)
- Over57.5 (+225)
- Under57.5 (-315)
- Over58.0 (+245)
- Under58.0 (-350)
- Over58.5 (+250)
- Under58.5 (-360)
- Over59.0 (+260)
- Under59.0 (-375)
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - Arizona Cardinals
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - San Francisco 49ers
San Francisco 49ers @ Arizona Cardinals | Total Points O/U
- Over - 1H22.0 (-200)
- Under - 1H22.0 (+145)
- Over - 1H22.5 (-185)
- Under - 1H22.5 (+140)
- Over - 1H23.0 (-180)
- Under - 1H23.0 (+130)
- Over - 1H23.5 (-150)
- Under - 1H23.5 (+115)
- Over - 1H24.5 (-110)
- Under - 1H24.5 (-120)
- Over - 1H25.5 (-105)
- Under - 1H25.5 (-125)
- Over - 1H26.0 (EVEN)
- Under - 1H26.0 (-130)
- Over - 1H26.5 (+105)
- Under - 1H26.5 (-135)
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - Arizona Cardinals
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - San Francisco 49ers
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - Arizona Cardinals
San Francisco 49ers @ Arizona Cardinals | Total Points O/U - San Francisco 49ers
Score Props
Back to Game LinesSan Francisco 49ers @ Arizona Cardinals | First Half Winning Margin
- 49ers by 1-3 points - 1H+1000
- Cardinals by 1-3 points - 1H+900
- 49ers by 4-6 points - 1H+1100
- Cardinals by 4-6 points - 1H+900
- 49ers by 7-9 points - 1H+1000
- Cardinals by 7-9 points - 1H+750
- 49ers by 10-12 points - 1H+1400
- Cardinals by 10-12 points - 1H+900
- 49ers by 13 or more points - 1H+700
- Cardinals by 13 or more points - 1H+300
- Tie - 1H+850
San Francisco 49ers @ Arizona Cardinals | Winning Margin
- Tie+5000
- Cardinals by 1-6 points+330
- 49ers by 1-6 points+450
- Cardinals by 7-12 points+425
- 49ers by 7-12 points+750
- Cardinals by 13-18 points+600
- 49ers by 13-18 points+1200
- Cardinals by 19-24 points+850
- 49ers by 19-24 points+2200
- Cardinals by 25-30 points+1400
- 49ers by 25-30 points+4000
- Cardinals by 31-36 points+2200
- 49ers by 31-36 points+6600
- Cardinals by 37-42 points+4000
- 49ers by 37-42 points+10000
- Cardinals by 43 or more points+4000
- 49ers by 43 or more points+10000
San Francisco 49ers @ Arizona Cardinals | First Score Method
San Francisco 49ers @ Arizona Cardinals | First Score Method - Cardinals
San Francisco 49ers @ Arizona Cardinals | First Score Method - 49ers
San Francisco 49ers @ Arizona Cardinals | Odd/Even Total Points
San Francisco 49ers @ Arizona Cardinals | Double Result
San Francisco 49ers @ Arizona Cardinals | Points Range
San Francisco 49ers @ Arizona Cardinals | Race To 10
San Francisco 49ers @ Arizona Cardinals | Race To 15
San Francisco 49ers @ Arizona Cardinals | Race To 20
San Francisco 49ers @ Arizona Cardinals | Race To 25
San Francisco 49ers @ Arizona Cardinals | Race To 30
San Francisco 49ers @ Arizona Cardinals | Race To 35
San Francisco 49ers @ Arizona Cardinals | Race To 40
Touchdown Props
Back to Game LinesSan Francisco 49ers @ Arizona Cardinals | First Touchdown Scorer - Arizona Cardinals
San Francisco 49ers @ Arizona Cardinals | First Touchdown Scorer - San Francisco 49ers
San Francisco 49ers @ Arizona Cardinals | Anytime Touchdown Scorer
- Dan Arnold+260
- Christian Kirk+175
- DeAndre Hopkins-125
- Darrell Daniels+750
- Kendrick Bourne+210
- Jeff Wilson (SF)+105
- Tevin Coleman+300
- Jordan Reed+275
- KeeSean Johnson+400
- River Cracraft+750
- Brandon Aiyuk (SF)+160
- Kyler Murray-125
- Richie James (SF)+300
- Ross Dwelley+750
- Kyle Juszczyk+750
- Jerick McKinnon+185
- Maxx Williams+550
- C.J. Beathard+375
- Kenyan Drake-165
- Larry Fitzgerald+330
- Chase Edmonds+200
San Francisco 49ers @ Arizona Cardinals | Who will Score 2 or more Touchdowns?
- Richie James (SF)+3300
- Jeff Wilson (SF)+700
- Chase Edmonds+1800
- KeeSean Johnson+5000
- C.J. Beathard+4000
- Maxx Williams+8000
- Kyler Murray+450
- Darrell Daniels+10000
- Larry Fitzgerald+3300
- DeAndre Hopkins+500
- Jerick McKinnon+1800
- River Cracraft+10000
- Dan Arnold+2800
- Brandon Aiyuk (SF)+1400
- Tevin Coleman+3300
- Kenyan Drake+330
- Kyle Juszczyk+10000
- Christian Kirk+1600
- Jordan Reed+2800
- Kendrick Bourne+2000
- Ross Dwelley+10000
Game Props
Back to Game LinesSan Francisco 49ers @ Arizona Cardinals | Team to score last in the game
San Francisco 49ers @ Arizona Cardinals | Will the team that scores first win the game?
San Francisco 49ers @ Arizona Cardinals | The first score of the game - Exact outcome
San Francisco 49ers @ Arizona Cardinals | First offensive play of the game
San Francisco 49ers @ Arizona Cardinals | Will the game go to Overtime?
San Francisco 49ers @ Arizona Cardinals | Will there be a safety in the game?
San Francisco 49ers @ Arizona Cardinals | Team to Record Most First Downs in the Game
San Francisco 49ers @ Arizona Cardinals | Team to Record the First Turnover in the Game
San Francisco 49ers @ Arizona Cardinals | The first turnover of the game will be
San Francisco 49ers @ Arizona Cardinals | Team to Call the First Timeout in the Game
San Francisco 49ers @ Arizona Cardinals | Team to Get the First Penalty in the Game
San Francisco 49ers @ Arizona Cardinals | First Team To Score
Punt Props
Back to Game LinesSan Francisco 49ers @ Arizona Cardinals | Team to have the most punts in the Game
By David Limbaugh, on 4:30p ET